A-PRF (Advanced Platelet Rich Fibrin)

Why Choukroun’s A-PRF?

Many recent studies have shown the interest and potential of white cells in the inflammatory cascade, as a corollary, a prominent action in the early days of stimulation of osseo-progenitor cells. (Omar & Thomsen, Biomaterials, 2012, Kawazoe T, Cell. Transplant 2012)

It was therefore natural to try to capture the whole amount of monocytes in the PRF, to make it more active in stimulating bone grafts, but also to turn to a more rapid transformation of monocytes into macrophages to increase the effect bone stimulation.

This is done with the A-PRF or Advanced-PRF.

The concept of PRF (Platelet Rich Fibrin) is based on the centrifugation of whole blood without anticoagulants. (J. Choukroun et al. 2001). At the end of the spin, a fibrin clot containing the majority of the platelets and white blood cells is obtained.

This fibrin clot called Platelet Riche Fibrin or PRF will release gradually and growth factors or cytokines in the site (VEGF, PDGF, TGF Beta, Thrombospondin)

The expected objective of these growth factors is to accelerate the soft tissue and bone healing.

Numerous international publications (143) are available and demonstrate the effectiveness of PRF in many indications: oral surgery (implants, bone grafting, periodontal surgery, extractions, etc…), Orthopedic, cosmetic and dermatological surgery.

Today, the PRF is recognized around the world, from Nice to New York from Los Angeles to Shanghai, from Rangoon to Moscow, from Sao Paulo to Cape Town, Santiago to Zagreb…

Its effectiveness is definitely proven.

Indications:

Sinus lift
Implants
Bone grafting
Excelled Wound Healing
Soft Tissue Augmentation
Tooth Extractions